Alzheimer disease (AD) is a neurological disorder characterized by slow, progressive memory loss due to a gradual loss of brain cells. AD significantly affects cognitive (thought) capabilities and, eventually, affected…
Alzheimer’s disease, the major cause of dementia in the elderly, affects over 5 million Americans. It is estimated that this devastating disorder strikes someone in America every 72 seconds. Unless…
Dopamine is the common chemical mediator in the brain that mediates all addictive drugs’ rewarding properties. However, the exact role of dopamine in the two key components of reward, incentive…
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Dr. Dawson’s laboratory focuses on Batten disease, a neurodegenerative disease that results in mental retardation and premature death. Batten disease is a lysosomal storage disease in which undigested proteins accumulate…
Sleep is considered restorative and important for illness recovery. In converse, sleep disruption has been shown to adversely affect recovery from illness by reducing cognition, immune function, respiratory drive and…
Cerebral salt Wasting leading to hyponatremia in patients with aneurysmal SAH can be a devastating entity. Its pathophysiology is not well understood yet. Establishing a causal relationship between marinobufagenin and…
The ultimate goal of this work is to develop new treatments for pathological aggression based on a mechanistic understanding of its neurobiology. We know from extensive research in rodents and…
High grade gliomas represent the most common primary malignant tumor of the adult central nervous system. Unfortunately, the median survival after surgical intervention alone is only 6 months and the…
Aberrant gene expression is a possible cause of some complex diseases including bipolar disorder and schizophrenia. However, regulation mechanisms of gene expression, especially in the brain, remain unknown for most…
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