Charcot-Marie Tooth (CMT) comprises a group of inherited peripheral neuropathies. One formof CMT called hereditary liability to pressure palsies (HNPP) is manifest by recurrent episodesof traumatic or compressive peripheral neuropathies.…
This project will use a rat model of peri-operative ischemic optic neuropathy (ION) to examinemechanisms of axonal injury and to provide important new data to understand and prevent animportant clinical…
Males and females of most species display pronounced sexual dimorphisms. These extend tothe nervous systems and include distinct anatomical and functional features, which areultimately manifested in behavioral differences (Kandel, 2000).…
The central nervous system (CNS) is composed of three principal cell types: neurons,astrocytes, and oligodendrocytes. In recent years, it has become increasingly clear that glialcells are important for many of…
Our long-term goal is to use genetic markers to identify neurons that regulate motor functionsand transgenic mouse models to understand their contribution to the rhythmic motor output. Wehave identified a…
Dr. Sam S. Sisodia’s seed grant focuses on Alzheimer’s disease which is characterized bydegeneration of the brain due to the accumulation of toxic peptides called Abeta peptides.Abeta is derived from…
Excessive or uncontrollable aggression is a highly destructive force in society. Pathological aggression is a relatively common problem that occurs in a number of psychiatric disorders. Furthermore, genetic factors have…
The incidence of autistic spectrum disorders has recently been estimated to be as high as 1 out of every 166 births. It has become generally accepted that autism, in its…
Imagine walking into a crowded party for the first time. It can be a little disorienting – people fill the room but it’s difficult to identify anyone. Over the course…
Dr. Kristen Jacobson, an associate professor of psychiatry at The University of Chicago, has always been interested in environmental experiences and their effect on behavior, but thought there was something…
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