The cerebellum controls movement. When neural signals in the cerebellum are disrupted, people and other animals cannot precisely control their muscles and become uncoordinated, giving rise to ataxia and dystonia,…
Insight from Dr. Penzes’ research will help scientists understand how connections in brain cells are disrupted in autism, and may uncover a viable therapeutic target that has real potential as…
Expansion of a polyglutamine (polyQ) tract in huntingtin (Htt) protein represents the primary event leading to neuronal degeneration in Huntington’s disease (HD), but the molecular mechanisms mediating mutant Htt (polyQ-Htt)…
Prion diseases are neurodegenerative diseases caused by the generation of a misfolded form of the prion protein (PrP). Genetic mutations within the PrP gene act to destabilize PrP, causing it…
These studies will determine how the activity of the brain reward area called “ventral tegmental area” is modulated by specific inputs from another brain reward area called “lateral habenula”. To…
This proposal plans to test the hypothesis that a specific type of neuron, highly important for the early development of the cortex, is affected either in its functions or structure…
Dr. Lazarov’s investigation of neurogenesis in adult stem cells will lead to greater understanding of Alzheimer’s disease. When Dr. Orly Lazarov sought to understand certain cellular processes associated with…
Autism Spectrum Disorder (ASD) is a brain disorder with devastating consequences for social interaction skills, which is further characterized by repetitive behavior and language impairment. Here, we want to test…
When a food is eaten to satiety, the pleasantness of its smell and taste are reduced. The important consequence of this effect, referred to as “sensory-specific satiety,” is to diminish…
Periventricular Heterotopia (PH) caused by mutations of the Filamin gene is a congenital brain developmental disease that affects both brain structures and functions. A mouse model of PH by inactivating…
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