This proposal plans to test the hypothesis that a specific type of neuron, highly important for the early development of the cortex, is affected either in its functions or structure…
Expansion of a polyglutamine (polyQ) tract in huntingtin (Htt) protein represents the primary event leading to neuronal degeneration in Huntington’s disease (HD), but the molecular mechanisms mediating mutant Htt (polyQ-Htt)…
We will determine how galectins, a family of proteins secreted by many types of cells, alter brain function through specific interactions with glutamate receptors, which are important signaling molecules involved…
Autism Spectrum Disorder (ASD) is a brain disorder with devastating consequences for social interaction skills, which is further characterized by repetitive behavior and language impairment. Here, we want to test…
Neural stem and progenitor cells generate the massive diversity of neurons and glia that comprise the nervous system. Understanding the regulation of how neural progenitors divide and differentiate will provide…
Her investigations into neurorepair will support Dr. Ardelt’s clinical work with stroke patients and also have the potential to advance the treatment of other brain disorders. Suffering a stroke leaves…
Neuromodulatory inputs to the neocortex play a central role in regulating the behavioral state of an animal. The neuromodulator acetylcholine (ACh), in particular, is essential for arousal and attention. Cholinergic…
We will determine how galectins, a family of proteins secreted by many types of cells, alter brain function through specific interactions with glutamate receptors, which are important signaling molecules involved…
The neurodegenerative disease amyotrophic lateral sclerosis (ALS; Lou Gehrig’s disease) is a fatal paralytic disorder characterized by cell death of corticospinal neurons. Early in the disease process cortical circuits are…
Dr. Jamie Roitman, Assistant Professor of Psychology at the University of Illinois at Chicago (UIC), is interested in understanding the neural mechanisms that underlie decision-making. Failure to engage in appropriate…
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