Parkinson Disease (PD) is a common, disabling condition characterized by progressive slowness of movement and loss of the brain chemical dopamine. Though it has been known for more than 40…
Understanding the neural basis of mental diseases such as schizophrenia and autism is a major challenge in neuroscience. One major roadblock is the lack of basic understanding of how neural…
This work will determine mechanisms by which BTBD3, the first gene associated with human OCD by GWAS, influences OCD-related behaviors in mice. In addition to the results we will obtain…
Traumatic brain injury is a growing cause of acquired cognitive disability in the US. Considerable progress has been made to understand how the brain responds to traumatic brain injury yet…
Model experimental systems, such as mice, are often used to investigate the mechanisms of neurological disease. However, it would be ideal to examine the causes of disease and test potential…
The G-protein coupled receptor superfamily is the most commonly targeted group of molecules for the treatment of human diseases. Adhesion-type GPCRs are a newly discovered GPCR family with emerging roles…
A remarkable feature of brain development and function is that it not only relies on a genomic blueprint, but also depends on sensory experience and the resulting activity communicated within…
Alzheimer’s disease (AD) is a prevailing disease with no treatment. AD is caused by imbalanced production and clearance of Abeta peptides in the brain, leading to neurotoxic Abeta oligomers. Current…
Cell division is a fundamental mechanism used by stem cells to produce more differentiated cells. In the developing brain neural progenitors generate both neurons and progenitors during a process called…
Mental disorders represent the single greatest burden of all human diseases, and currently available treatments do not meet the need of most patients. Mental illnesses are associated with changes in…
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