We aim to develop a new class of multifunctional sensors that respond to chemical signals in the brain through quantum physics and that can be probed using light. The sensors…
Glioblastoma is a devastating form of brain cancer with no known cure. The existence of different types of cancer cells with diverse biological properties in the same glioblastoma tumor significantly…
The diversity of neuronal cells in the human brain is thought to be reflected by the tremendous diversity of RNA molecules generated in each neuron by the process of alternative…
Protein metabolism plays a key regulatory role in the nervous system, in both health and disease. Learning and memory functions in particular require ongoing synthesis of new proteins. With a…
This proposal seeks to understand how an important protein modification called ‘ubiquitination’ regulates signaling in the brain. Defects in ubiquitination are linked to multiple neurodegenerative and neuropsychiatric disorders (e.g. autism,…
Glutamate is a chemical neurotransmitter that plays a critical role in facilitating synaptic communication between neurons and receptors in the brain. Normal brain processes, such as those that underlie cognition,…
The soft, 3-dimensional (3D) nature of brain tissues requires that interrogating bioelectronics possess similar mechanical characteristics and dimensionality to such tissues. However, conventional electronics are typically constructed from hard, planar…
Optical imaging has been a fantastically powerful tool for studying the activity of neurons in functional circuits. However, current tools are based on a reversible sensing approach that restricts neurobiologists…
1) Lipid signaling plays an essential role in synaptic transmission and aberrant lipids signaling has been implicated in many brain diseases including AD, Down’s syndrome and epilepsy; however, we know…
Despite the clinical importance, the mechanisms underlying most chronic itchy conditions remain unknown due to a lack of information about principal pruritogens and itch receptors. Previously, we identified several novel…
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