A longstanding question in neuroscience concerns the cellular mechanisms of learning and memory. Since synapses were first discovered as the sites of communication between neurons, scientists have thought that changes in their number or structure would be a likely substrate of memory. Although ev...
A “burst” is a brief period of high-frequency activity in a neuron, an event that can have a powerful impact on brain circuits. Overly-exuberant bursting—for example, when bursts occur repeatedly…
Dr. Saltzman and his lab propose an innovative and potentially transformative approach for the correction of single-gene disorders of the central nervous system in the fetal brain: in utero administration…
Many neuropsychiatric disorders, including autism and schizophrenia, are thought to arise from disruptions in brain wiring. However, the tools for studying brain wiring are limited in resolution and throughput. Dr.…
The neocortex is the part of our brains that we use for our highest cognitive functions. The main neurons of the neocortex can be lost due to neurodegenerative diseases such…
Could a child with epilepsy be given a pill containing an all-but-invisible therapeutic device programmed to travel to specific cells in his brain and, once there, be “pinged” into action…
All of our conscious perceptions and cognitive actions depend critically on the neural computations performed by cortical circuits—the network of connections made by neurons in the cerebral cortex. Given the…
A 2000 Nobel Prize winner, Dr. Greengard is developing innovative technology that will lead to better understanding of the molecular mechanisms behind Parkinson’s disease. Paul Greengard, Ph.D., professor of molecular…
Dr. Castellanos is elucidating the neuroscience of ADHD and its relationship to substance abuse through genetic studies and sophisticated brain imaging. Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric condition that, until…
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